Control of lymphatic filariasis by annual single-dose diethylcarbamazine treatments
Identifieur interne : 00BE88 ( Main/Exploration ); précédent : 00BE87; suivant : 00BE89Control of lymphatic filariasis by annual single-dose diethylcarbamazine treatments
Auteurs : E. Kimura [Japon] ; J. U. Mataika [Fidji]Source :
- Parasitology Today [ 0169-4758 ] ; 1996.
Abstract
It has long been stressed that diethylcarbamazine citrate must be given at a total dosage of 72 mg per kilogram of body weight in 12 divided doses of 6 mg kg−1 to obtain maximum effect against Wuchereria bancrofti. However, recent studies revealed that only a single dose at 6 mg kg−1 could reduce microfilaria (Mf) counts by 90%, and that the effect would persist for 12–18 months. The annual repeat of the single-dose mass treatment was shown to be effective in reducing Mf prevalence and density in large-scale, long-term field trials. The scheme is simple and economic, and could be sustainable in many endemic areas, where health manpower and resources are often not sufficient. Annual single-dose mass treatments can be an effective weapon against human lymphatic filariasis, as discussed here by Eisaku Kimura and Jona Mataika.
Url:
DOI: 10.1016/0169-4758(96)10014-4
Affiliations:
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